Integrated approach to the study of hematological diseases and the immune system /
Medicine - Hemostasis and Thrombosis
Study of blood disorders with altered coagulation mechanism
The research team deals with both hemorrhagic and thrombotic diseases, congenital or acquired, including hemophilia, rare coagulation defects, platelet disorders and von Willebrand disease, venous thrombosis, arterial thrombosis and thrombotic microangiopathies, and complement diseases. In addition, there is a line of research concerned with the standardization of laboratory methods.
In particular, the molecular basis and pathophysiological mechanisms of coagulopathies, risk factors contributing to their development, optimization of their medical therapy and reduction of complications, to gene therapy are studied. Research is conducted from genetic/genomic, biochemical, proteomic, cell biology, bioinformatics, as well as epidemiological and clinical perspectives.
The group is also engaged in intensive clinical research oriented particularly toward the testing of innovative drugs for the treatment of hereditary coagulopathies. The research group in recent years has been working on phase I, II and III clinical trials and new therapies in both hemorrhagic and thrombotic areas. with participation in clinical trials. Of particular note are studies on gene therapy for the treatment of hemophilia.
Incucyte® SX5 (Sartorius): In vivo monitoring of cell parameters such as viability, proliferation cell functions, movement and morphology.
Chromium Controller: 10X Genomics: for single cell analysis
BD FACSCelesta™ (BD Biosciences): Cytofluorimetry system
ACL Acustar (Werfen): A fully automated analyzer of highly sensitive immunoassays based on chemiluminescent technology
ACL TOP 700 (Werfen): Fully automated hemostasis testing systems for routine and specialized testing
Hydrasys 2 scan (Sebia): An all-in-one compact multi-parameter system for agarose gel electrophoresis
LX 200 (Luminex): A flexible analyzer based on the principles of flow cytometry that allows simultaneous measurement of up to 80 analytes in a single microplate well
ROTEM Delta (Werfen): Analysis covers the entire whole blood clotting process
- International Society on Thrombosis and Haemostasis (ISTH)
- World Federation of Hemophilia (WFH)
- American Society of Hematology (ASH)
- World Federation of Hemophilia (WFH)
Hemophilia and coagulation defects laboratory team: 1 full professor, 2 laboratory technicians, 2 biologists, 2 biotechnologists, 1 health researcher, 1 statistician, 2 PhD health researchers.
Platelet disorders laboratory team: 2 biologists, 1 health researcher.
Von Willebrand disease laboratory team: 1 biologist, 1 laboratory technician, 2 health researchers.
Thrombosis and thrombotic microangiopathies laboratory team: 1 full professor, 1 associate professor, 1 laboratory technician, 1 biotechnologist, 1 health researcher, 1 biologist, 1 statistician.
Laboratory team of complement and coagulation in immunological diseases: 1 full professor, 1 health researcher, 1 laboratory technician.
Laboratory team of standardization of diagnostic procedures and hemostasis: 1 biologist, 2 health researchers.
Hemorrhage Clinical Trials: 2 hematologists, 2 internists, 2 physical therapists, 1 associate professor, 4 study coordinators.
Clinical studies in the thrombotic field: 5 hematologists, 4 study coordinators.
Thrombotic Clinical Trials:5 hematologists, 4 study coordinators.
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Related Core Facilities
Updated at 10:07 of 18/07/2023
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Integrated approach to the study of hematological diseases and the immune system
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